Myelodysplastic syndromes (MDS) - When bone marrow fails
Myelodysplastic Syndromes (MDS) are blood cancers where the bone marrow fails. Learn about MDS symptoms, causes, diagnosis, and treatment options.
17 September, 2025Unexplained fatigue or frequent infections? Understanding Myelodysplastic Syndromes (MDS), a group of bone marrow disorders, is crucial for early diagnosis and improving your prognosis. Don't dismiss persistent, vague symptoms.
What are the main causes of Myelodysplastic Syndromes?
- The exact causes of MDS are often unknown; this is called primary or de novo MDS, and it occurs without any obvious predisposing factor.
- Secondary MDS can be caused by prior cancer treatments, such as chemotherapy or radiation, which can damage bone marrow stem cells years later.
- Exposure to certain chemicals like benzene and a history of other blood disorders can also increase the risk of developing these syndromes.
Key symptoms of Myelodysplastic Syndromes to watch for
- The most common myelodysplastic syndrome symptoms are related to low red blood cell counts, causing severe fatigue, weakness, and shortness of breath.
- Frequent infections due to low white blood cells and easy bruising or bleeding from a low platelet count are also key warning signs.
- Some people may experience unexplained fevers, bone pain, and unintentional weight loss, which warrant a thorough medical evaluation for an MDS diagnosis.
How can you prevent Myelodysplastic Syndromes effectively?
- For most people, there is no known way to prevent primary MDS, as the causes are not fully understood and it often develops randomly.
- Limiting long-term exposure to known industrial chemicals, such as benzene, and avoiding tobacco smoke may help reduce your overall risk.
- While necessary, being aware that certain cancer therapies are a risk factor allows for careful monitoring by doctors after treatment is complete.
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Image of the disease Myelodysplastic Syndromes
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An accurate MDS diagnosis is key to determining the best MDS treatment plan and prognosis. If you have concerning symptoms, consult a hematologist for evaluation.
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