Acromegaly - When the body produces too much growth hormone

The changes are often slow, but the impact of acromegaly is significant. Recognizing the early symptoms is critical for effective management. Don't overlook the subtle signs of this rare hormonal disorder.

What are the main causes of Acromegaly?

• The condition is almost always caused by a non-cancerous pituitary tumor that produces excessive amounts of growth hormone, disrupting normal body functions.
• This overproduction of growth hormone leads to the overgrowth of bones and soft tissues, which defines the physical characteristics of the disorder.
• When this hormonal excess occurs in childhood before the growth plates have closed, it results in a related condition known as gigantism.

Key symptoms of Acromegaly to watch for

• The most noticeable signs are the gradual enlargement of the hands and feet and changes in facial features like a protruding jaw.
• Individuals may also experience thickened skin, excessive sweating, joint pain, and a deepening of the voice due to enlarged vocal cords.
• Headaches, vision problems, and symptoms of diabetes or heart disease are also common complications that require prompt medical evaluation and care.

How is Acromegaly diagnosed and treated?

• Diagnosis is confirmed through blood tests that measure levels of growth hormone and IGF-1, followed by imaging scans to locate the tumor.
• The primary acromegaly treatment is often surgery to remove the pituitary tumor, which can normalize hormone levels and relieve associated symptoms.
• If surgery isn't fully effective, medications like somatostatin analogs may be used to control growth hormone production and manage the condition long-term.

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Microscopic images of Acromegaly

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Early and effective management is key to preventing long-term complications from acromegaly. If you recognize these symptoms, consult an endocrinologist for a thorough evaluation and to discuss a personalized treatment plan.

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